A brief History of US Route 1, America’s first interstate highway. U.S. Route 1 is a major north–south U.S. Highway that serves the East Coast of the United States. It runs 2,390 miles (3,846 km) from Key West, Florida, north to Fort Kent, Maine, at the Canadian border. U.S. 1 generally parallels Interstate 95, though … Continue reading US Route 1 – This is where it all begins